Trimethylsilyl Inflate in organic synthesis 3905 The actual nucleophilic species involved in the reaction may be trimethylsilyl isocyanide. The reaction of 4t butylcyclohexanone leads to a mixture of 25 and 26 with the former predominating (25: 26 91: 9). Trimethylsilyl triflate C4H9F3O3SSi CID structure, chemical names, physical and chemical properties, classification, patents, literature, biological Trimethylsilyl purum, 98.
0 (T) Synonym: TMS triflate, TMSOTf, acid trimethylsilylester Trimethylsilyl is a derivate with a trimethylsilyl Rgroup. It has similar reactivity to trimethylsilyl chloride, and is also used often in organic synthesis. Synthesis of methyl triflate by the reaction of silver triflate with methyl iodide [23.
Later on Booth et al. [24 used triflic anhydride as a starting material for the synthesis of methyl triflate, CF3SO2OCH3, via reaction with methanol (Scheme 2). Scheme 2. Synthesis of methyl triflate by the reaction of triflic anhydride with methanol [24. Trimethylsilyl is a trialkylsilyl triflate used as a catalyst in organic synthesis. Trimethylsilyl is used in combination with boron trifluoride eth yl ether to prepare a Lewis acid that is more powerful than its components and especially effective in acetonitrile solvent.
Synthesis of LinkerFunctionalized Resin 1. (4. 6 g, 11 mmol, 4. 0 equiv. ) was dissolved in DMF (20 ml) and cooled to 0. NaH (60 dispersion in mineral oil, 0.
53 g, 11 mmol, 4. 0 equiv. ) was As a silylating agent for the synthesis of trimethylsilylenol ethers from esters of diazoacetoacetic acid.
To activate benzyl and allyl ethers for the alkylation of sulfides. To facilitate the conversion of DielsAlder adducts of Danishefskys diene to cyclohexenones without the formation of methoxy ketone byproduct.